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- 1st team appearance of Infinity Watch: Adam Warlock, Drax the Destroyer, Moondragon, Gamora, Pip the Troll and Thanos
- Each member was given control of one Infinity Gem
- Origin of Venom and Eddie Brock
- Retelling of the incident that occurred in Web of Spider-Man #18 where Peter was pushed in front of a train by who was originally intended to be a woman seeking revenge for her family who were accidentally killed during a fight between Spider-Man and an enemy. The sequence in this issue shows Eddie Brock pushing Peter in front of the train. This moment was also told in The Amazing Spider-Man #388 as was the other pre-appearance attack that occurred in Web of Spider-Man #24