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- 1st appearance of Spider-Zero
- *speculation that she is related to Miles in some way, possibly his sister (baby sister in Miles Morales Spider-Man #14 has the same stuffed animal in her crib as Spider-Zero has clipped to her belt)
- 1st appearance of Spider-Monster and Lord Spider
- 1st appearance of fan-created spider personas: Spider-Requiem, V and The Spinster