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- 1st cover and cameo appearance of Bishop (final panel)
- 1st cameo team appearance of the X.S.E., the Xavier Security Enforcers: Bishop, Malcolm, Randall
- [October 2020 - speculation surrounding Bishop's introduction to the MCU due to his connection to time travel and the confirmation of Kang]
- 1st full appearance of Bishop, a time-traveling mutant who can absorb and redistribute energy
- 1st appearance of the Gamemaster, a powerful mutant telepath