1st appearance of the symbiote that later bonds with Gwen to become Gwenom

1st appearance of Dr. Elsa Brock, the Eddie Brock of Gwen Stacy's reality

1st appearance of Speedball

First artwork on Spider-Man by Mark Bagley

Origin of Chthon in a back-up story, how his essence was locked away in Wundagore Mountain - story continues in X-Men Annual #12 (1988)

First solo series featuring Ironheart, Riri Williams

First mention of the Ten Rings terrorist organization in mainstream Marvel Universe

1st appearance of Angela

later acquired by Marvel as Thor's half sister

1st appearance of Medieval Spawn

1st appearance of Cogliostro

Cover inspired by Wonder Woman #72

1st appearance of Star, the physical host of the Infinity Reality Stone

Copies ordered by retailers: 32,939

1st appearance of Kick-Ass

Copies ordered by retailers: 47,811

2nd appearance and first cover of Spot

1st appearance of Quantum, the assistant of the Assessor

2nd appearance of America Chavez

Cover art by Gabriele Dell'Otto featuring Bullseye

Thor is revealed to be Jane Foster and that she is fighting late stage cancer

2nd cameo appearance of the Dark Multiverse Batmen (visible briefly, previous cameo obscured in shadows): The Drowned, The Dawnbreaker, The Red Death, The Batman Who Laughs, The Merciless, The Devastator, The Murder Machine

1st appearance of Baby Darkseid

First one-on-one battle of the Hulk vs She-Hulk

Earlier issues, The Incredible Hulk #321 and #322 depicted a fight but Bruce Banner was separated from the body of the Hulk and other characters were engaged in the battle

1st full appearance of Marchion Ro

Debut of Wolverine's Weapon X design in full, with helmet

1st appearance of Miles Morales from Earth-616 as Ultimatum

Reintroduction of the Ultimate Green Goblin

Origin of Starling

1st full appearance of Gaslamp

1st appearance of Brother Blood

1st appearance of Mother Mayhem

1st appearance of Baron Winters

1st cameo appearance of The Monitor, voice only

Preview of Night Force

1st appearance of White Dragon, Daniel Ducannon

1st appearance of Green Lantern, Sojourner Mullein

Premiere issue of the third She-Hulk series

Cover appearance of Spider-Punk

1st appearance of Kang the Conglomerator

1st appearance of Miles Morales from Earth-616, an evil version of the character who later becomes Ultimatum

1st appearance of Zodiac, an anarchist in possession of the Zodiac Key

1st appearance of Kyle Rayner, final page, later becomes the third Green Lantern

1st appearance of Alexandra DeWitt, Rayner's girlfriend who is brutally murdered in the controversial issue Green Lantern #54

1st appearance of Leopardon in a comic book, a giant robot operated by Spider-Man (Supaidaman), originating from a live-action 1970s Japanese television show

2nd cameo appearance of Web-Slinger

[December 2018 - Leopardon is teased in a sketch by Miles in a notebook / Nov 2019 - writer Phil Lord seemingly confirmed the Japanese Spider-Man when he admitted that the character was already designed which could have been referring to the 2018 Easter Egg]

Partial cover appearance of Spider-Punk, in upper right corner

📖 Spider-Verse Reading Order: read The Amazing Spider-Man #12 (2014 series), then Spider-Man 2099 #7

Iconic cover art by Erik Larsen

1st appearance of Sleeper, the result of Eddie Brock bonding with the infant Symbiote

What if..."Silver Surfer Possessed the Infinity Gauntlet"

Variant cover art by Sara Pichelli

1st cover and cameo appearance of Bishop, in final panel

1st cameo team appearance of the X.S.E., the Xavier Security Enforcers: Bishop, Malcolm, Randall

[October 2022 - Bishop rumored to be in X-Men '97 animated series]

1st team appearance of the Outsiders: Batman, Black Lightning, Halo, Geoforce, Katana and Metamorpho

1st appearance of Katana, a Japanese martial artist

1st appearance of Geoforce, has the ability to manipulate Earth's gravity

1st appearance of Halo, has the ability to create auras of light with different effects

1st appearance of Jackie Estacado, later becomes the Darkness

[October 2022 - Marc Silvestri is teasing an adaptation without much additional detail which could be to generate sales for a new upcoming comic series]

1st cover appearance of America Chavez, seen on the cover of a comic book being tossed by Nick Fury Jr.

Preview of Young Avengers #1 (2013)

1st full appearance of Phage

1st full appearance of Agony

1st full appearance of Riot

1st full appearance of Lasher

First battle of Punisher versus Moon Knight

Brother Voodoo becomes Sorcerer Supreme in the mainstream Marvel universe

Reintroduction and new origin of Jason Todd after Crisis on Infinite Earths reset the DC mainstream universe

1st appearance of Ma Gunn, the headmistress of a school that trains young boys to be criminals

"Crisis on Infinite Earths" part 8

Death of Flash, Barry Allen

1st appearance of the Red Hulk, in-story, appeared only on the cover of Hulk #1 (2008)

1st appearance of A-Bomb, later revealed to be Rick Jones

First battle of Punisher vs Wolverine

1st appearance of Bucky as Captain America

Cletus Kasady becomes infected by the Venom symbiote, later becomes Carnage

1st cameo appearance of Eddie Brock, hands only, pushing Peter Parker into the path of an oncoming train

The hands that push Peter Parker in this panel were intended to be those of a woman who lost her family in an accident, indirectly caused by Spider-Man but eventually Eddie became the main antagonist in the symbiote suit

This scene is retold from Brock's perspective in The Amazing Spider-Man #388

1st appearance of Yuriko Oyama as Lady Deathstrike, in costume - previously introduced in Daredevil #197

1st appearance of the third Ghost Rider, a Mexican-American woman named Alejandra Jones

Preview of Jones in Ghost Rider #0.1

Copies ordered by retailers: 41,308

1st appearance of Mojo

2nd cameo appearance of Carnage including mention by name, a hand, an arm and partial face

1st team appearance and origin of the Champions: Ms. Marvel, Spider-Man, Nova, Hulk, Viv Vision, Cyclops

1st appearance of Puck, a superb fighter with no mutant powers

1st appearance of Marrina, wife of Namor

1st appearance of Tundra, a member of the Great Beasts

1st cameo appearance of Wild Child

1st appearance of Madison Jeffries

1st cameo team appearance of Gamma Flight, a team training to rise the ranks through Beta Flight to Alpha Flight

First battle of Daredevil versus the Punisher