1st appearance of Alioth, the supreme being of the Timespan

1st appearance of Kang Swaach, Kang Raulex and Kang Kaseo, members of the Council of Cross-Time Kangs

Holo-foil cover

1st appearance of Ahura Boltagon, the son of Black Bolt and Medusa as a Kang variant

1st appearance of Pharaoh Rama-Tut, later revealed to be the time-traveler Kang the Conqueror

Stan Lee first uses the phrase "Nuff Said" in the Special Announcements section

1st appearance of Immortus, aka Kang and Rama-Tut

Debut of the call-to-action, 'Avengers Assemble' said by Thor

1st cover appearance of Valkyrie, cover only, not in interior story

1st appearance of Khan, an older Kamala Khan

1st cameo appearance of the Time Eater, an alternate reality Kang occupying the corpse of Galactus

Cover appearance of Spider-Punk

1st appearance of Kang the Conglomerator

1st appearance of Kid Immortus

1st appearance of Miss Kang (Ms. Marvel/Kang)

1st appearance of Moon Squirrel (Moon Girl/Squirrel Girl)

1st team appearance of the Council of Kangs

1st appearance and death of a Kang variant that killed the Avengers in an alternate timeline

1st appearances of unknown Kangs and Kang robots

[July 2021 - potential of multiple Kang variants to be introduced in the MCU]

1st appearance of Anno Kang

1st appearance of Kang the Immortal, the Earth-X version of Kang

Marrina Smallwood, wife of Namor, becomes Leviathan

1st appearance of Kang Orphan, a young boy

1st cameo appearance of Kang-Nebula, Ravonna Renslayer

1st team appearance of the Council of Cross-Time Kangs

Battle of the original Avengers (1963) versus the new Avengers (1968)

1st appearance of Scarlet Centurion, the third identity of Kang the Conqueror

1st team appearance of the Young Avengers: Kate Bishop, Patriot, Asgardian aka Wiccan, Hulkling, and Iron Lad, who is later revealed to be a young variant of Kang

[October 2022 - Hulkling and Wiccan aka Billy Kaplan, son of Scarlet Witch are rumored to appear in the Agatha TV series / Wiccan likely to be portrayed by Joe Locke (Heartstopper) / New casting of Miles Gutierrez-Riley speculated to be in the role of Hulkling]

1st appearance of Mesozoic Kang, a reptilian variant of Kang

1st team appearance of the Kang Collective

1st appearance of Kangaroo the Conqueror

1st appearance of Chairman Kang, leader of the Council of Kangs

1st appearance of Kang of Other Earth

1st full appearance of Kang-Nebula, Ravonna Renslayer

1st cameo appearance of Kang Cobra

1st cameo appearance of Namor and Marrina's children, egg hatchlings

1st appearance of Kang, the original version

[December 2020 - Jonathan Majors is confirmed as Kang for five MCU projects including Quantumania]