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Symbiotes
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- Hulk bonds with the Venom symbiote
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- 1st appearance of Sleeper, the result of Eddie Brock bonding with the infant Symbiote
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- 1st appearance of Patricia Robertson as Scream, formerly She-Venom
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- 1st appearance of Spider-Man's black costume
- Cover swipe of Amazing Fantasy #15
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- 1st full appearance of Normie Osborn as Goblin Childe
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- 1st appearance of N'Jadaka, the new Emperor bonded to a symbiote
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- 1st team appearance of The Mercury Team, a US task force deployed to hunt down symbiotes utilizing the Life Foundation symbiotes (Phage, Lasher, Agony and Riot)
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- Origin of Symbiotes
- 1st appearance of the planet Klyntar, named after the Symbiote word for "cage”, comprised of Symbiote mass with Knull's physical body at the center
- 1st mention of the team Agents of the Cosmos
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- 1st appearance of Gorr, the God Butcher
- 1st appearance of the Necrosword, created by Knull
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- 1st full appearance of Knull, the symbiote god
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- 1st full appearance of Carnage
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