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Symbiotes

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  • 1st appearance and origin of Lee Price, bonds with the Venom symbiote
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  • Origin of Gorr the God Butcher
  • 1st cameo appearance of Knull the Symbiote God
  • [July 2020 - in the panels where Knull made his first cameo, he is fighting against a character in golden armor. The identity of this character is unknown but there is speculation that the golden-armored god might be developed further or appear soon]
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  • 1st cover appearance of Ultimate Venom
  • 1st appearance of the synthetic symbiote in the beaker that later bonds to The Maker
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  • Dr. Conrad Markus becomes Venom
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  • 1st appearance of Gwen Stacy as Gwenom
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  • April Parker becomes Mayhem, a clone of May Parker genetically and a hybrid human/symbiote
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  • Preview appearance of Bile, a cannibalistic madman with the strength and eating habits of a spider
  • *Bile was presented as a joke in this issue but CBR posts an article about Donny Cates taking an interest in the character even though it seemed the tweet exchange was more conversational without future plans
  • *character never appeared in a story but bears similar horror attributes as Spiders-Man of Earth 11580 (See Spider-Verse button)
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  • 1st appearance of Carla Unger, a scientist who briefly bonded with the Carnage symbiote
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  • Hulk bonds with the Venom symbiote
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  • 1st appearance of Marcus the Centaur Werewolf Symbiote Warrior
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  • 1st appearance of Sleeper, the result of Eddie Brock bonding with the infant Symbiote
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  • Deadpool bonds with Hybrid
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  • 1st appearance of Patricia Robertson as Scream, formerly She-Venom
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  • 1st cameo appearance of the symbiote planet of Klyntar (unnamed)
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  • 1st appearance of Captain Corsair
  • 1st cameo appearance of Brood Thor
  • 1st cameo appearance of a new symbiote in a jar
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  • 1st appearance of Spider-Man's black costume
  • Cover swipe of Amazing Fantasy #15
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  • 1st full appearance of Normie Osborn as Goblin Childe
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  • 1st team appearance and origin of the Exolon, parasites made of living darkness created by Knull
  • 1st team appearance of the Nameless, a group of lost Kree explorers infected by the Exolon
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  • 1st appearance of N'Jadaka, the new Emperor bonded to a symbiote
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  • 1st appearance of Pork Grind, a Spider-Ham Universe version of Venom
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  • Variant cover art by Jay Anacleto featuring the Carnage Queen, Mary Jane Watson
  • 1st cover appearance of the Carnage Queen
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  • Janet Van Dyne (Wasp) is overtaken by a symbiote virus along with a number of other heroes
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  • 1st appearance of Addy Brock, pilot of the mechanized Ven#m suit
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  • 1st team appearance of The Mercury Team, a US task force deployed to hunt down symbiotes equipped with the Life Foundation symbiotes: Phage, Lasher, Agony, Riot
  • *copies ordered by retailers: 30,378
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  • 1st appearance of Karl Malus as Superior Carnage
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  • 1st team appearance of the Vipers, a female squadron of symbiote assassins led by Venom
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  • 1st full appearance of Phage
  • 1st full appearance of Agony
  • 1st full appearance of Riot
  • 1st full appearance of Lasher
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  • 1st appearance and 1st cover appearance by Venom 2099
  • Variant cover art by Rick Leonardi
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  • Origin of Symbiotes
  • 1st appearance of the planet Klyntar, named after the Symbiote word for "cage”, comprised of Symbiote mass with Knull's physical body at the center
  • 1st mention of the team Agents of the Cosmos
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  • 1st appearance of Gorr, the God Butcher
  • 1st appearance of the Necrosword, the first symbiote created by Knull

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