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1st full appearance of Venom

Peter Parker returns to his classic red-and-blue costume

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1st appearance of Cletus Kasady, later becomes Carnage

1st full appearance of Cardiac, a doctor who vowed to find a cure for the ailment that caused the death of his brother

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Cletus Kasady becomes infected by the Venom symbiote, later becomes Carnage

[March 2026 - a glimpse of Spider-Man battling Boomerang in the Brand New Day trailer was inspired by this cover - tap cover and swipe to view screenshot]

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1st cameo appearance of Carnage, in one panel - a glob of red symbiote material can be seen

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2nd cameo appearance of Carnage including mention by name, a hand, an arm and partial face

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1st full appearance of Carnage, spawned from the extraterrestrial parasite known as the Venom symbiote

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1st appearance of Ann Weying, Eddie Brock’s ex-wife who later becomes She-Venom

1st appearance of Carl Brock, Eddie's father

First team-up of Spider-Man and Venom

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1st appearance of Shriek, a mutant ally of Carnage

Shriek appears in Venom II

Introduction of Ravencroft Institute for the Criminally Insane

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1st appearance of Pat Mulligan, later becomes Toxin

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