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  • Origin of Doctor Strange, specifically the car accident that damaged his hands
  • Origin of Baron Mordo
  • 2nd appearance of the Sandman
  • 1st mention of Dormammu
  • 1st mention of the Vishanti: Agamotto, Hoggoth, Oshtur
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  • 1st partial cover appearance of Doctor Strange
  • 1st appearance of the Orb of Agamotto
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  • 1st appearance of the Avengers 1,000,000 BC: Agamotto, Black Panther, Iron Fist, Lady Phoenix, Starbrand, Odin and Ghost Rider
  • 1st appearance of Zgreb the Aspirant AKA The Fallen, a Celestial who befell the same fate as the Progenitor