- 1st appearance & origin of Captain America
- 1st appearance of James Buchanan Barnes aka Bucky (later becomes the Winter Soldier)
- 1st appearance of the Red Skull (George Maxon), an agent of the true Red Skull
- 1st appearance of Hurricane, (later becomes Makkari) and Tuk the Cave Boy (first offspring of the Inhumans)
- A CGC 2.0 copy sold at the Heritage Platinum Session Signature Auction (Sept 2020) for $90k.
- A 2.5 copy had previously sold in June of 2019 for $90k.
- The last 2.0 sale was in 2012 for $24k representing approx. a 275% increase.
- Captain America Comics #1 is one of the absolutely most sought after comics in history and is often designated the vaunted mega key status.
- Very few copies remain in existence. The CGC census has tracked approx. 90 copies ever given a universal grade with another 80 given the less desirable restored grade.
- While incredibly small these numbers are still larger than than those for the big 3 of collecting: Action Comics #1 (41 universal grade copies exist), Detective Comics #27 (32 universal grade copies exist) and Marvel Comics #1 (just 30 universal grade copies exist).