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- 1st appearance of Shang-Chi, the Master of Kung-Fu
- 1st appearance of Sir Dennis Nayland-Smith
- 1st appearance of Fu Manchu, father of Shang-Chi, in a Marvel title
- *in-development and will be the first film headlined by an Asian character for Marvel
- 1st appearance of Spider-Man's black costume
- Published simultaneously to Amazing Spider-Man #252 & Marvel Team-up #141
- 1st use of the half red & blue, half black costume logo