1st appearance of Microbe, communicates with microscopic organisms

1st appearance of Debrii, weaponizes nearby objects using telekinesis

Cover art by Sana Takeda with allusions to a sub-genre of Japanese adult entertainment that focuses on tentacled alien aggressors

Characters on the cover include Misty Knight, Colleen Wing, Black Cat and Tarantula (Maria Vasquez)

Origin of Eddie Brock, as an adolescent

Origin of Venom, the symbiote suit bonds with Eddie

Story expands on a back-up story that began in The Amazing Spider-Man Annual #26 ( 1992)

Origin of Venom and Eddie Brock

Retelling of the incident that occurred in Web of Spider-Man #18 where Peter was pushed in front of a train by who was originally intended to be a woman seeking revenge for her family who were accidentally killed during a fight between Spider-Man and an enemy. The sequence in this issue shows Eddie Brock pushing Peter in front of the train. This moment was also told in The Amazing Spider-Man #388 as was the other pre-appearance attack that occurred in Web of Spider-Man #24

Three-issue limited series featuring Anti-Venom, Eddie Brock versus The Punisher

Anti-Venom versus The Punisher

Team-up of Anti-Venom and The Punisher

1st appearance of Tanis Nieves, later becomes Scorn

Copies ordered by retailers: 32,794

Copies ordered by retailers: 28,334

Copies ordered by retailers: 29,466

1st appearance of Scorn, a spawn of Carnage

Premiere issue of a five-part limited series where Carnage sets his sights on a small American town to terrorize

1st appearance of The Mercury Team, a US task force deployed to hunt down symbiotes equipped with the Life Foundation symbiotes: Phage, Lasher, Agony, Riot

Mercury Team was a Sym-Soldier program that became known as Project Venom

Copies ordered by retailers: 30,378

Copies ordered by retailers: 28,272

Copies ordered by retailers: 28,707

Copies ordered by retailers: 28,652

1st appearance of Kaldera, daughter of Proxima Midnight

Nova, Alexander joins The New Warriors

1st appearance of Macrothrax

1st full appearance of Vespa, the Specter of Hornets

1st full appearance of Thread, the Silkworm Ghoul

1st full appearance of Tusk, the Rhino-Beetle Hulk

1st team appearance of the Kang Collective

1st appearance of Kangaroo the Conqueror

1st team appearance of the Hellions: Mister Sinister, Scalphunter, Wild Child, Empath, Nanny, Oprhanmaker, Psylocke, Havok

Chapter 18: X of Swords

1st appearance of Tarn the Uncaring

1st team appearance of the Locus Vile

48-page one-shot

While hunting on Christmas Day, a father and son provoke the wrath of Santa after mistaking a reindeer for common game

1st appearance of ZETA Team, a brutal mercenary squad

1st appearance of an A.I. self-replicating mutant

1st appearance of Queen Goblin, Ashley Kafka

Variant cover art by Mark Bagley

Origin of Queen Goblin

Ben Reilly becomes Chasm, formerly Scarlet Spider

Premiere issue of the seventh Amazing Spider-Man series

Variant virgin cover art by Rose Besch

Variant cover art by Esad Ribic

1st appearance of Sinister Adaptoid, a being equipped with the powers of the Sinister Six

1st appearance of the Living Brain, an upgraded version of the classic villain

Milestone issue #900

Variant cover art by Julian Totino Tedesco

Variant cover art by Jim Cheung

Variant cover art by John Romita Jr.

Variant cover art by Peach Momoko

Debut of Oscorp Spider-Man suit, seen but not worn

Variant design cover art by Patrick Gleason

Debut of Oscorp Spider-Man suit being utilized, seen in a closet in issue #7

1st cover appearance of Gold Goblin

1st appearance of Gold Goblin

2022 Local Comic Shop Day variant

VIEW MORE LOCAL COMIC SHOP DAY EXCLUSIVES UNDER THE LCSD 2022 CATEGORY

1st appearance of Hallow's Eve

Variant cover art by Ed McGuinness featuring Hallow's Eve

1st team appearance of the Insidious Six, a demonic version of the Sinister Six

1st appearance and origin of Rek-Rap, a demonic Spider-Man variant

Variant cover art by Lorenzo Pastrovicchio