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- Debut of Iron Man's 'Extremis' armor, a combination of nanotech with Stark's advanced armor enhancing the whole but more importantly, giving Tony the power to control his machinery with his thoughts
- ***cameo of armor still in a suitcase in issue #4
- 1st appearance of Knowhere, a celestial's decapitated head re-purposed as a space station at the edge of the universe
- 1st appearance of Cosmo, a Russian cosmonaut dog with telepathic abilities
- 1st team appearance of the Luminals, Knowhere's security detail led by Cynosure