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1st team appearance of the X-Men: Cyclops, Jean Grey aka Marvel Girl, Iceman, Angel, Beast, Professor X

1st appearance of Magneto

Homo Superior concept, coined by Magneto to describe humans born with special abilities introduced in this issue

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1st appearance of the Blob, an invulnerable mutant

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1st team appearance of the Brotherhood of Evil Mutants led by Magneto

1st appearance of Scarlet Witch

1st appearance of Quicksilver

1st appearance Mastermind, later becomes Jason Wyngarde

1st appearance of Toad

2nd appearance of Magneto

Although the Scarlet Witch's costume is colored green on the cover, it is red in the story

First interaction between Charles Xavier and Magneto, though their origins have since been retconned to have them meet earlier in their lives

Uncanny X-Men #12

Marvel 1965 Vol. 1
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1st appearance and origin of the Juggernaut

Origin of Professor X

1st cameo appearance of Cyttorak, as a statue, the demonic elder god whose Crimson Bands and ruby gemstone gave Juggernaut great powers

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1st appearance of the Sentinels, machines invented to hunt mutants

1st appearance of Dr. Bolivar Trask, creator of the Sentinels

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Debut of new powers, Jean Grey is reborn as the Phoenix

Ten years later this moment would be further developed where the Phoenix is an actual cosmic entity of vast power that copied Grey’s physical form while placing her body in a cocoon to heal from her injuries

1st full appearance of Black Tom Cassidy

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1st full appearance of Mystique, revealed without disguise

[April 2021 - when keying in a number sequence on the Buccaneer Bay section of Marvel’s exploremadripoor.com, an image with the name Mystique appears in a boat charter reservation]

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1st appearance of the Shadow King, Amahl Farouk, a powerful psychic

Origin of Professor X concerning a difficult psychic battle against Amahl Farouk which was the inspiration to create the X-Men

Professor X recalls his first encounter with Storm

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1st cameo appearance of Mutant X aka Proteus, the son of Moira MacTaggert

Cameo appearance of DC's Phantom Stranger and Popeye in the background art of a party hosted by Empress Lilandra

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The Dark Phoenix Saga Part 1

1st appearance of Kitty Pryde

1st appearance of Emma Frost, the White Queen

1st cameo team appearance of The Hellfire Club, in shadows

[January 2024 - Kitty Pryde rumored for the X-Men MCU reboot according to a casting grid]

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The Dark Phoenix Saga Part 6

Jean Grey becomes the Dark Phoenix

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"God Loves, Man Kills"

1st appearance of General William Stryker

1st team appearance of the Purifiers

1st appearance of Kitty Pryde as Ariel, formerly Sprite - new costume debut occurred in Uncanny X-Men #169

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1st full appearance and cover of Apocalypse

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1st full appearance of Mr. Sinister

[July 2022 - Mr. Sinister rumored to be a villain in the X-Men reboot]

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1st full appearance of Cable

1st full team appearance of the Mutant Liberation Front: Stryfe, Wildside, Reaper, Fourarm, Thumbelina, Strobe, Tempo, Zero

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1st full appearance of Onslaught, a creation born from the mind of Charles X and Magneto

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