Low $30
 | 
Mid $115
 | 
High $315
  • 1st appearance of the High Evolutionary, a geneticist obsessed with evolutionary experimentation
  • 1st appearance of Man-Beast, a wolf modified by the High Evolutionary
  • 1st cameo appearance of Fafnir
  • [September 2020 - speculation that High Evolutionary will appear in Guardians of the Galaxy Vol. #3 and tie into Rocket's origin]
Details
Publisher Marvel
Published November 1966
Written By Stan Lee
Illustrated By Jack Kirby