1st appearance and origin of the Flash, Barry Allen

1st appearance of Iris West, the wife of Barry Allen

This issue is credited for ushering in the Silver Age of comics

1st team appearance and origin of the Legion of Super-Heroes: Cosmic Boy, Lightning Boy, Saturn Girl

1st appearance of Cosmic Boy

1st appearance of Lightning Boy, later becomes Lightning Lad

1st appearance of Saturn Girl

1st appearance and origin of Brainiac

1st appearance of the Bottle City of Kandor, the capital city of Krypton

1st appearance and death of Bizarro Superboy

[March 2022 - Superman & Lois TV show features Bizarro as a main villain]

1st appearance and origin of Adam Strange

1st appearance of Alanna, daughter of Sardath

1st appearance of Sardath, a scientist from Rann who created Zeta-Beams

1st appearance and origin of Mr. Freeze, initially named Mr. Zero, later renamed Mr. Freeze in Detective Comics #373

1st appearance and origin of Mirror Master

Barry Allen appears for the first time in the Flash title

1st appearance of Supergirl

1st appearance of Metallo

1st appearance of Zor-El, the father of Supergirl

1st full appearance of Sgt. Rock

1st appearance and origin of Hal Jordan as Green Lantern

1st appearance Carol Ferris, later becomes the second Star Sapphire

1st appearance and death of Abin Sur, an alien who gave Hal his ring as he died

First mention of the Green Lantern Corps

1st team appearance of the Suicide Squad: Rick Flag, Jess Bright, Karin Grace, Hugh Evans

The first iteration of the Suicide Squad preceded the formation of the Justice League of America by three issues

1st team appearance of the Justice League of America: Superman, Batman, Wonder Woman, Flash, Green Lantern, Aquaman

1st appearance of Starro the Conqueror

1st appearance of Oa, the planetary headquarters of the Green Lantern Corps

1st appearance of Puppet Master

1st team appearance of the Guardians of the Universe

First solo-titled Justice League of America series

1st appearance of Despero

1st appearance of Groot, an alien resembling a tree

1st appearance of Bat-Girl, Betty Kane

1st appearance and origin of Sinestro, known as the greatest of all Green Lanterns until it was discovered he used the power ring to enslave the sector he was charged to protect

1st appearance and origin of The Atom aka Ray Palmer, in the Silver Age

1st appearance of Jean Loring, girlfriend of Ray Palmer

1st appearance of the Golden Age Flash in the Silver Age

Key issue of the Mutliverse concept

2nd appearance of The Shade

First mention of Earth-2, home of the Golden Age superheroes

[March 2022 - rumor that Warner Bros. will incorporate a Crisis on Infinite Earths event (which was already adapted for TV) in The Flash movie in an effort to streamline their universe of live-action projects. If this is the scenario, a Multiverse concept will first have to be established as it did in this issue]

1st appearance of Fin Fang Foom, translated his name means 'he whose limbs shatter mountains and whose back scrapes the sun'

1st appearance of Dr. Chan Liuchow, a member of the Legion of Night

1st team appearance and origin of the Fantastic Four: Mr. Fantastic, Invisible Woman, Human Torch, The Thing

1st appearance of Mole Man

1st appearance of Tricephalous

Landmark issue that launched the Marvel Age of comics

💰 In April 2022, a 9.2 sold for $1.5 million

[SDCC 2022 - Phase 6 will open with the Fantastic Four film]

1st appearance and origin of Hank Pym, later becomes Ant-Man, Goliath, Giant-Man and Yellowjacket

1st team appearance of the Skrulls, the shape-shifting alien race

2nd team appearance of the Fantastic Four

Premiere issue of the first Aquaman title series

1st appearance of Qwsp, a creature from the 5th dimension and ally of Aquaman

1st team appearance of the Fantastic Four in costume

1st appearance of the Miracle Man

1st appearance of the Baxter Building, Fantastic-car and Fantastic-copter

1st appearance and origin of the Hulk

1st appearance of Betty Ross

1st appearance of Rick Jones

1st appearance of General "Thunderbolt" Ross

1st appearance of Sub-Mariner in the Silver Age

First time the Human Torch activates his power while shouting, 'Flame On'

2nd appearance of the Hulk, first time with green skin, previously gray

1st appearance and origin of Doctor Doom

[November 2020 - speculation that Doom will be hinted at or appear in the Black Panther sequel as well as other MCU projects]

1st appearance and origin of Thor

Introduction of Thor's hammer, Mjolnir

1st team appearance of the Kronans, a race of rock-like aliens

1st appearance of Donald Blake, the human host of Thor

2nd appearance of Thor

1st appearance and cover of Jane Foster

1st appearance and origin of Spider-Man

1st appearance and death of Uncle Ben

1st appearance of Aunt May

1st appearance of Flash Thompson

💰 In Sept. 2021, a 9.6 sale of $3.6 million surpassed the previous record in this grade of $1.1 million from 2011

1st appearance of Loki, the Norse god of mischief

1st appearance of Balder, half-brother of Thor

1st appearance of Heimdall, guardian of Bifrost

1st appearance of Tyr, the Norse god of war

1st cameo appearance of Odin, the All-Father, seen from behind

3rd appearance of Thor

1st appearance of Iron Man

Debut of Iron Man's 'Model 1' armor

1st appearance of Wong-Chu, a Viet Cong warlord and Iron Man's first enemy

2nd appearance of Spider-Man

First meeting of Spider-Man and the Fantastic Four

1st appearance of Chameleon, Dmitri Smerdyakov, half-brother of Kraven the Hunter

[February 2022 - confirmed, Fred Hechinger cast as chameleon]

1st appearance of J. Jonah Jameson

First battle of the Hulk and the Fantastic Four

First crossover of a character with a title (the Hulk) into another title (Fantastic Four)

3rd appearance of Spider-Man

1st appearance of Vulture

1st appearance of the Terrible Tinkerer

1st cameo appearance of Mysterio, disguised as the assistant of the Terrible Tinkerer

Spider-Man first references his ability to sense danger as his Spider-Sense tingling

[June 2022 - Jorma Taccone to voice Vulture in Spider-Verse 2]

1st appearance of Sgt. Nick Fury

1st team appearance of the Howling Commandos: Happy Sam Sawyer, Dino Manelli, Dum Dum Dugan, Junior Juniper, Rebel Ralston and Gabe Jones, the first ongoing black character in the mainstream Marvel Universe (post Fantastic Four #1)

In the book, Stan Lee's Amazing Marvel Universe, Stan explains Gabe Jones was intended to be black but due to a printing error, he was the same color as the other soldiers. Gabe's skin tone is noticeably different in the next issue though not necessarily a natural color

December 2020 - Fury confirmed to lead his own series alongside Talos in Secret Invasion]

1st appearance and origin of the Wasp

1st team appearance and origin of Doom Patrol: Chief, Negative Man, Elasti-Girl, Robotman

1st appearance of Doctor Strange

1st appearance of the Ancient One, former Sorcerer Supreme

1st appearance of Wong, Doctor Strange's assistant

[May 2022 - Wong to appear in She-Hulk Disney+ series]

1st cameo appearance of Nightmare, multiple panels, named but obscured by shadows

1st appearance, cover and origin of Dr. Octopus

Debut of the 'Spider's Web' fan letters section

An editing error has Doctor Octopus mistakenly refer to Spider-Man as Super-Man

1st appearance and origin of Professor Zoom, Eobard Thawne aka Reverse-Flash

1st appearance and origin of Sandman

1st appearance of Betty Brant, a secretary at the Daily Bugle

Spider-Man refers to himself as 'The Friendly Neighborhood Spider-Man' for the first time

1st cameo appearance of Jessica Jones, a spectator of the Sandman versus Spider-Man fight - this appearance is retconned as revealed in The Amazing Spider-Man #601

1st team appearance of the X-Men: Cyclops, Jean Grey aka Marvel Girl, Iceman, Angel, Beast, Professor X

1st appearance of Magneto

Homo Superior concept, coined by Magneto to describe humans born with special abilities introduced in this issue

1st team appearance and origin of the Avengers: Hulk, Iron Man, Wasp, Thor, and Ant-Man, Pym

1st appearance and origin of the Lizard

1st appearance of the Blob, an invulnerable mutant

1st appearance and origin of Electro

[December 2021 - a source informs us that there was a clause in Foxx’s contract that secured his reprisal of the Electro role for a standalone feature if No Way Home hit an opening weekend monetary goal but we cannot say for sure that an Electro spin-off will happen]

1st appearance of Mandarin